Birdshot Chorioretinopathy : Prospective Follow-up and Immunogenetic Studies(CO-BIRD)

Plain-language summary

This observational study prospectively follows patients with birdshot chorioretinopathy, an inflammatory eye disease, and investigates the immune and genetic aspects of the condition. It is enrolling patients who have disease in both eyes and meet the diagnostic criteria. This study has no assigned phase and is still recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

Assistance Publique - Hôpitaux de Paris

Intervention

Observational study

Start date

11/2/2004

Estimated completion

12/31/2030

Countries

France

Related genes

Locations

• Paris, France

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

1. Bilateral disease
2. Presence of at least three peripapillary "birdshot lesions" inferior or nasal to the optic disk in one eye
3. Low-grade anterior segment intraocular inflammation (defined as ≤ 1+cells in the anterior chamber)
4. Low grade vitreous inflammatory reaction (defined as ≤ 2+ vitreous haze‡) Supportive findings

1\. HLA-A29 positivity 2. Retinal vasculitis 3. Cystoid macular edema

Exclusion Criteria:

1. Keratic precipitates
2. Posterior synechiae
3. Presence of infectious, neoplastic, or other inflammatory diseases that can cause multifocal choroidal lesions