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This study examines the drug LOXO-260 in cancer patients who have a change (fusion or mutation) in the RET gene and have not responded to prior treatment. It enrolls mostly patients aged 18 and older with locally advanced or metastatic cancer who have previously received a selective RET inhibitor. The study is being conducted in Phase 1 and is active but not currently recruiting.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Must be ≥ 18 years of age at the time of signing the informed consent (Phase 1a and Phase 1b). Patients 12 years and older may be enrolled in Phase 1b for countries and sites where approved. * Must have evidence of a previously documented RET fusion (solid tumors) or RET mutation (MTC or MEN2-associated cancers) that is a histological or a cytological proven diagnosis of locally advanced, unresectable and/or metastatic cancer and meet cohort-specific criteria. * Have received a prior selective RET inhibitor. * Eastern Cooperative Oncology Group (ECOG) score of 0 to 1 (age \> 16 years), Karnofsky Performance Status (KPS) ≥ 80 (age \> 16 years), or Lansky Performance Status (LPS) ≥ 40% (age \< 16 years). * Have discontinued all previous treatments for cancer with resolution of any significant AEs, and of all clinically significant toxic effects of prior locoregional therapy, surgery, radiotherapy, or systemic anticancer therapy. * Have adequate organ function. * Phase 1b expansion: Patients must have measurable disease per RECIST v 1.1. * Phase 1b expansion: Molecular Pathology Results (including RET and other genes) from a sample, blood or tissue, taken on or after RET selective treatment. Exclusion Criteria: * Disease suitable for local therapy administered with curative intent. * Have an active fungal, bacterial, and/or active untreated viral infection. * The patient has a serious pre-existing medical condition(s). * Have symptomatic CNS malignancy or metastasis. * Patients treated with drugs known to be strong inhibitors or inducers of cytochrome P450 3A (CYP3A). * Progression of disease within 4 months of starting a prior selective RET inhibitor. * Phase 1b expansion: Patients harboring known activating bypass alterations outside RET that may confer resistance to LOXO-260.