Propranolol and Von Hippel-Lindau Disease

Plain-language summary

This study evaluates the use of the drug Propranolol and patient follow-up in people with Von Hippel-Lindau disease who have one or more hemangioblastomas of the central nervous system. Patients aged 18 and older whose tumors do not require urgent surgery may take part. The study has no assigned phase and is still recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

Assistance Publique - Hôpitaux de Paris

Intervention

Propranolol, follow-up

Start date

1/16/2023

Estimated completion

11/1/2026

Countries

France

Related genes

Locations

• Le Kremlin-Bicêtre, France

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Age ≥ 18
* VHL patient with one or more hemangioblastomas of the central nervous system, none of which require urgent surgery (within 3 months)
* Patient with written consent to participate in the study
* Enrolled in a social security plan or beneficiary

Exclusion Criteria:

* Contraindication to the use of propranolol:
* chronic obstructive pulmonary disease and asthma,
* uncontrolled heart failure,
* 2nd and 3rd degree atrioventricular blocks,
* bradycardia (\<50 beats/minute after 3 minutes of rest),
* Raynaud's phenomenon and peripheral arterial disorders,
* arterial hypotension,
* hypersensitivity to propranolol
* cardiogenic shock,
* Prinzmetal's angina,
* sinus disease (including sino-auricular block)
* untreated pheochromocytoma,
* history of anaphylactic reaction,
* in the context of primary and secondary prevention of digestive bleeding in cirrhotics: advanced liver failure with hyperbilirubinemia, massive ascites, hepatic encephalopathy
* predisposition to hypoglycemia (as after fasting or in case of abnormal response to hypoglycemia)
* metabolic acidosis
* Contraindication to MRI:
* claustrophobia,
* presence of a pace maker and other stimulators/implants
* ocular metallic foreign bodies,
* heart valves or ferromagnetic metal vascular clips
* Patients already on Propranolol or other beta blockers
* Patients under guardianship or conservatorship
* Pregnant or breastfeeding women - Woman with a medium-term pregnancy project