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This study investigates the role of mitochondrial dynamics in aneurysm and dissection of the ascending thoracic aorta by analyzing mitochondrial dynamics and metabolic profiles in aortic tissue samples. It includes patients operated on for aortic aneurysm or dissection, along with comparison patients undergoing heart valve or bypass surgery. The study has no assigned phase and is currently active but not recruiting new participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Aneurysm aortic group: patients treated for an aneurysm of the ascending thoracic aorta with surgical indication according to the ESC guidelines (2014). * Aortic dissection group: patients treated for type A acute aortic dissection or intramural hematoma of the ascending thoracic aorta in emergency. * Control group: patients operated for aortic valve replacement (little aortic sample before closing aortotomy) or coronary artery bypass grafting which the use of a saphenous graft and the performance of a proximal anastomosis on the ascending aorta is planned Exclusion Criteria: * Patients under 18 years old * Other acute aortic syndromes (penetrating ulcers, iatrogenic or traumatic dissections) * Patients treated for aortic valve replacement in the context of infective endocarditis * Patients treated for emergency aortic valve replacement or coronary bypass surgery\*\* * Pregnant, parturient and breastfeeding women * Patients protected by an administrative or judicial measure (curatorship, guardianship) * Patients receiving psychiatric care under duress * Adults subject to a legal protection measure. * Patients whose the samples planned for the study could not be taken; * Patients in the control group whose tissue sampling will not be performed.