Antibiotyping and Prevalence of Virulent Genotypes Among Helicobacter Pylori and Their Impact on Response to Therapy

Plain-language summary

This study examines the antibiotic sensitivity (antibiotyping) of Helicobacter pylori and the prevalence of virulent genotypes such as VacA and CagA, and their impact on response to treatment, in patients with H. pylori infection. It included symptomatic, previously untreated patients over 18 diagnosed with H. pylori by a stool test. The study had no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Assiut University

Intervention

detection of vacuolating cytotoxin A (Vac A) and cytotoxin-associated gene A (Cag A) virulent H.Pylori genotypes by polymerase chain reaction amplification(PCR) in gastric biopsies :, Culture and sensitivity of endoscopic gastric biopsies:, Histopathological examination endoscopic gastric biopsies:, Upper endoscopy, empirical H.pylori regimens, H.Pylori Ag in stool

Start date

1/20/2024

Estimated completion

1/20/2025

Countries

Egypt

Related genes

Locations

• Asyut, Egypt

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

\- Any patient is above 18 years old with symptomatic H pylori infection patients diagnosed by positive H pylori Ag in stool (naïve treatment).

Exclusion Criteria:

* Patients who aren't eligible to endoscopy.
* Patients are under 18 years old
* Patient's refusal
* history of antibiotics or proton pump inhibitor use during last month.