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This is an observational study that examines the early biology of severe (critical) illness by collecting blood and various samples from people newly admitted to intensive care. Adults aged 18 and older who are admitted to the ICU shortly after presenting to the emergency department and show signs of critical illness are included. It is a non-interventional (observational) study and is currently recruiting.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Age ≥18 years old * ≤48h since ICU admission * ICU admission within 72h of presentation to the emergency department (ER) * Clinical critical illness suspected on the basis of any one of the following: 1. Altered mental status (GCS\<15) 2. Cardiovascular collapse (presence of any: Heart rate \>90, systolic blood pressure \<90, presence of vasopressors, lactate \>2.0) 3. Respiratory collapse (presence of any: respiratory rate \>20, PaCO₂ \<32 mm Hg, supplemental oxygen, invasive or non-invasive ventilation) 4. Suspected severe infection (presence of any: temperature \>38°C or \<36°C, white blood cell (WBC) count \>12,000/mm³ or \<4,000/mm³, presence of 1 or more antibiotics at the time of ICU admission) Exclusion Criteria: * Age \<18 years old * \>72h since ICU admission * Admission to ICU in patients \>72h after the presentation to the ER * No evidence of critical illness (ICU admission due to bed-spacing)