Evidence Based Probiotic Therapy of Proton Pump Inhibitor Induced Dysbiosis

Plain-language summary

This study investigates the effect of a probiotic therapy on gut flora imbalance (dysbiosis) that develops with long-term use of proton pump inhibitors. People older than 18 who have taken these medicines for at least 3 months may take part. It is a non-phase study that is currently active but not recruiting new participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Active, not recruiting

Sponsor

Medical University of Graz

Intervention

Intervention

Start date

7/10/2023

Estimated completion

7/1/2025

Countries

Austria

Related genes

Locations

• Graz, Austria

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Age \>18;
* Signed Informed Consent;
* PPI intake for at least 3 months;
* Willing to accept use of all encoded data, including publication, and the confidential use and storage of all data for at least 15 years; Exclusion criteria
* Diagnosed with a gastrointestinal infection within 4 weeks prior to screening; Severe gastrointestinal disorders (e.g. inflammatory bowel diseases)
* Received any of the following products/medication prior to screening: systemic antibiotics, prokinetics, prebiotic supplements, probiotic supplements within 4 weeks prior to screening;
* Concomitant diseases or other circumstances that suggest that the patients are not eligible for participation in the study