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This study evaluates screening for and treating Helicobacter pylori infection in adolescents in three regions of Chile, using a regimen of Lansoprazole, Amoxicillin, Clarithromycin, and Metronidazole to eradicate the infection. Healthy adolescents aged 14-18 with persistent H. pylori infection confirmed by testing may take part. It is a non-phase study and is currently enrolling participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: 1. Healthy teenagers 14-18 years of age from Colina, Temuco or Coyhaique 2. At least one responsible adult family member accessible for phone contact. 3. Persistent H. pylori infection determined by at least 2 positive UBT tests in a 3 months period (except for Non-infected Controls) Exclusion Criteria: 1. Teenagers not consenting to treatment will be invited to continue as non-treated controls. 2. Known allergy to any of the antimicrobials used in the trial protocol (except for Non-infected Controls) 3. Signs/symptoms compatible with organic abdominal pain according to Rome IV criteria: persistent right upper or right lower quadrant pain, dysphagia, odynophagia, persistent vomiting, gastrointestinal blood loss, involuntary weight loss, deceleration of linear growth, delayed puberty. 4. Prior eradication therapy 5. Antimicrobial course received during the previous month (at least 3 days of treatment at appropriate dosing, children meeting this criteria can be included at a later stage) 6. Pregnancy 7. Use of immunosuppressive or biologic drugs 8. Children deemed "not healthy" after review of the questionnaire by study physician