Mechanisms of Somatic Mutation and Tumor Initiation in Pre-malignant Kidney Tubule Cells

Plain-language summary

This study investigates how somatic mutations and tumor formation begin in kidney tubule cells in individuals with VHL disease, by collecting blood and urine samples. Individuals aged 25-65 with a genetically confirmed VHL diagnosis may take part. The study is being conducted as a non-phase study and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

IRCCS San Raffaele

Intervention

Blood and urine sample collection

Start date

6/30/2023

Estimated completion

12/31/2027

Countries

Italy

Related genes

Locations

• Milan, Italy

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Genetic diagnosis of VHL-disease; age (data need to be collected from a population distributed between 25 and 65 years); gender (males and females should be equally represented);

Exclusion Criteria:

* patients with bilateral nephrectomy, in dialysis or kidney transplant; use of nephrotoxic drugs