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This study explores the effect of a dietary intervention in people with mild-to-moderate atopic dermatitis/eczema. Adults aged 21-65 living in Singapore who are non-smokers, non-drinkers, and generally healthy can take part. It is a study without an assigned phase and is still enrolling participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: 1. Presence of current, mild-to-moderate atopic dermatitis/eczema at flexural areas 2. 21 to 65 years of age (inclusive) at screening 3. Must be English-literate and able to give informed consent in English 4. Be residing in Singapore and will not be travelling outside of Singapore during the study period 5. Reliable and willing to follow study procedures and be available for the duration of the study 6. Non-smokers (tobacco and e-cigarette) 7. Non-drinker (no regular or frequent consumption of alcohol) 8. Overtly healthy with no pre-existing medical conditions (e.g., diabetes, hypertension, cancer, blood disorders, degenerative/liver/autoimmune/immune/renal diseases, or psychiatric conditions) 9. No food allergies to test foods 10. No needle phobia 11. Be willing to follow the instruction provided by the investigators on the use of any moisturiser, cosmetics, and/or topical cream on the skin throughout the entire duration of the study. Exclusion Criteria: 1. Concurrent participation in other research studies 2. Pregnancy or lactating individuals 3. Known or ongoing psychiatric disorders within 3 years 4. Known severe nutritional deficiency 5. Vegetarian/vegans (as meat will be included in the diet) 6. Individuals who made a significant dietary change in the past 12 months 7. Having a pre-existing dietary restriction that would interfere with the adherence to a whole diet meal 8. Regular use of strong medication (western and/or traditional), therapies, and alternative medications 9. Regular nutritional supplements in the past 12 months Regular consumption of oral contraceptive pills and/or steroid hormones 10. Antibiotic use in the past 2 months 11. Any long-term hospitalisation or surgery during the 6 months before enrolment in study 12. Significant change in weight (+/- 5.0%) during the past month 13. History of bleeding diathesis or coagulopathy (or any bleeding disorders) 14. Having donated blood of more than 500 mL within 4 weeks of study enrolment