Evaluation Of DNA Methylation Pattern In Healthy, Sarcopenic, Obese And Sarcopenic Obese Older Women: A Cross-Sectional Study

Plain-language summary

This observational study compares the DNA methylation pattern (a type of chemical change that affects how genes work) in healthy, sarcopenic (loss of muscle mass), obese, and sarcopenic obese older women. It included sedentary older women meeting the relevant diagnostic criteria. It is a study without an assigned phase and is currently not recruiting but is still ongoing (active, not recruiting).

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Active, not recruiting

Sponsor

University of Sao Paulo

Intervention

None (Observational Study)

Start date

2/21/2024

Estimated completion

10/5/2024

Countries

Brazil

Related genes

Locations

• Ribeirão Preto, Brazil

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* body mass (menor 120 kg);
* sedentary (not practicing physical exercise for at least 3 months);
* not using vitamin or mineral supplements, anxiolytic medications, hypoglycemic agents with activity on cytochrome P450 (CYP450) enzymes;
* classified within the criteria for sarcopenic obesity, sarcopenia and obesity.

Exclusion Criteria:

* alcoholics;
* smokers;
* infectious diseases;
* coronary diseases;
* chronic kidney diseases and
* presenting a score ≤ 13 for the cognitive examination in the Mini-Mental State Examination (MMSE).