CARE-CRC: Microbiome Insights and Correlations for Risk and Outcomes in Colorectal Cancer

Plain-language summary

This observational study explores how the microbiome relates to risk and outcomes in colorectal cancer. People aged 40-74 living in Portugal who have a recent colorectal cancer diagnosis and have not yet started treatment may take part. It is a non-phase observational study that is currently recruiting.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

Gulbenkian Institute for Molecular Medicine

Intervention

No intervention: observational study

Start date

3/2/2026

Estimated completion

12/2/2029

Countries

Portugal

Related genes

Locations

• Lisbon, Portugal
• Lisbon, Portugal

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Be willing and able to provide written informed consent
* Resident in Portugal
* Age from 40 to 74 years
* Have a recent diagnosis of CRC without initiating any treatment.

Exclusion Criteria:

* Age \< 40 years or ≥ 75 years
* Unable to provide informed consent
* Refusal to provide stool samples
* Previous or current treatment for CRC
* First-degree family history of CRC
* Previous diagnosis of inflammatory bowel disease (ulcerative colitis, Crohn's disease or indeterminate colitis), inflammatory bowel syndrome, recurrent infection by Clostridioides difficile
* Pregnancy