Muscle Mass, Quality, and the Menopause: Sex-specific Strategies to Mitigate Sarcopenia in Ageing Populations

Plain-language summary

This study looks at the role of unilateral resistance exercise in reducing age-related muscle loss (sarcopenia) and the effects of menopause on muscle. Women aged 18 to 65 who are non-smokers and do not perform regular resistance exercise can take part. It is a study with no applicable phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

University of Nottingham

Intervention

Unilateral Resistance Exercise

Start date

7/29/2024

Estimated completion

3/1/2026

Countries

United Kingdom

Related genes

Locations

• Nottingham, United Kingdom

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Biological woman, 18-65 years of age
* Body mass index (BMI) 18-30 kg/m2
* Non smoker
* Not performing regular resistance type exercise
* Participant is willing and able to give informed consent for participation in the study

Exclusion Criteria:

* A BMI \<18 or \>39 kg·m-2
* Active cardiovascular disease: uncontrolled hypertension (Blood pressure \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event.
* Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
* Respiratory disease including pulmonary hypertension or Chronic obstructive pulmonary disease (COPD).
* Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), polycystic ovarian syndrome (PCOS), inborn/ congenital errors of metabolism (e.g. Phenylketonuria (PKU), galactosaemia)
* Active inflammatory bowel disease.
* Acute infection.
* Acute or chronic renal disease.
* Malignancy (or history of malignancy with 5 y).
* Recent (within 6 mo) or current steroid treatment, hormone replacement therapy (HRT), hormonal contraception, or other hormonal therapies that may interfere with outcome measures.
* Coagulopathy.
* Musculoskeletal or neurological disorders.
* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance.
* Amenorrhoea for a reason other than menopause.
* Contraindications for Magnetic Resonance Imaging (MRI).
* Allergy or sensitivity to local anaesthesia, or dressing adhesive.
* Inner ear pathology or vertigo