Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis

Plain-language summary

This study evaluates the clinical efficacy of a 1% Metformin and alendronate gel used together with platelet-rich fibrin in chronic periodontitis, a gum disease. Systemically healthy adults aged 25-50 with gum pockets of a certain depth were enrolled. Sponsored by Bahria University, this Phase 4 study is active but not currently recruiting.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Phase 4

Status

Active, not recruiting

Sponsor

Bahria University

Intervention

Platelet rich fibrin, Metformin hydrochloride powder, alendronate sodium powder

Start date

1/22/2025

Estimated completion

9/30/2027

Countries

Pakistan

Related genes

Locations

• Islamabad, Pakistan

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* • Males and females

  * Age 25-50 years
  * Systemically healthy individuals
  * Probing depth sites ≥ 5mm- \<7 mm pocket depth (PD)\[American Dental Association/ Academy of Periodontology 1999) Clinical attachment level (CAL) ≥4mm- \<5 mm \[ American Dental Association/ Academy of Periodontology 1999)
  * Vertical bone loss (VBL) ≥3mm on intraoral periapical radiographs.\[American Academy of Periodontology Guidelines, 1999\]
  * Modified Sulcus bleeding index (mSBI) \[Muhlemann and Sons index,1971; Augusta B Rebelo et al,2011\]
  * No history of periodontal treatment in the previous 6 months

Exclusion Criteria:

* • Individuals \<20 and \>50 yrs

  * Patients with known systemic disease such as diabetes, hypertension, osteoporosis etc.
  * Patients with severe periodontitis
  * Pregnant and lactating mothers
  * Patients receiving medications