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This study investigates the role of the STAT3 gene in the interaction between epithelium and microbiome during periodontitis and peri-implantitis (forms of gum inflammation). It included people aged 18 and older with healthy gums, periodontitis, or peri-implantitis. It was conducted as a study without an assigned phase and has been completed.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: Patients in the gingival health group: 1. Meet the case definition of gingival health (Chapple et al. 2018). 2. ≥ 18 years of age. 3. Willingness to donate gingival tissue and collect microbiological samples for the study. Patients in the periodontitis group: 1. Meet the case definition of periodontitis (Papapanou et al. 2018). 2. ≥ 18 years of age. 3. Willingness to donate gingival tissue and collect microbiological samples for the study. Patients in the peri-implantitis group: 1. Meet the case definition of periodontitis and peri-implantitis (Berglundh et al., 2018). 2. ≥ 18 years of age. 3. Willingness to donate gingival tissue and collect a microbiological sample for the study. Exclusion Criteria \- 1. Having used systemic antibiotics (intravenous, intramuscular, or oral) in the last six months. 2\. Having used corticosteroids or other immunosuppressants (e.g., cyclosporine), cytokine therapy, methotrexate, or any other immunosuppressive chemical agent, or high-dose commercially available probiotics (≥ 108 colony-forming units per day) in tablet, capsule, or powder form within the last three months. The use of fermented foods/liquids, e.g., milk, yogurt, etc., does not apply to the exclusion of the individual. 3\. Being pregnant or breastfeeding. 4. Subjects who cannot give consent.