Single Step Protocol and Multi-step Warming Protocol for Blastocyst FET

Plain-language summary

This study compares a single-step warming protocol with the standard multi-step protocol for thawing blastocysts in frozen embryo transfer. It is open to women aged 18 and older who have had no more than 3 prior IVF/ICSI cycles, have at least one good-quality frozen blastocyst, and agree to single embryo transfer. It is a study without an assigned phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

Mỹ Đức Hospital

Intervention

Single-step warming protocol by thawing solution only, Standard warming protocol

Start date

8/13/2025

Estimated completion

3/1/2027

Countries

Vietnam

Related genes

Locations

• Ho Chi Minh City, Vietnam

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Women aged from 18
* Undergoing no more than 3 previous IVF/ICSI cycles
* Had at least a single good-quality blastocyst frozen.
* Endometrium preparation using artificial cycle
* Agree to single blastocyst transfer
* Not participating in any interventional studies at the same time

Exclusion Criteria:

* Embryos from cycles after in-vitro maturation, pre-implantation genetic testing (PGT)
* Having contraindications for exogenous hormone administration (e.g., breast cancer, thromboembolic disease)
* Having uterine abnormalities (e.g., adenomyosis, intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx or endometrial polyp)