Multimodal Prehabilitation Program That Combines Physical Exercise, Psychological Intervention and Nutritional Support to Improve the Response to Neoadjuvant Chemoterhapy in Early Breast Cancer Patients

Plain-language summary

This study evaluates a multimodal prehabilitation program that combines physical exercise, psychological support, and nutritional support to improve the response to neoadjuvant chemotherapy (chemotherapy given before surgery) in patients with early-stage breast cancer. It can include patients aged 18 and over who have non-metastatic breast cancer and are candidates for neoadjuvant chemotherapy. This is a non-phase study and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

Hospital Clinic of Barcelona

Intervention

Multimodal prehabilitation

Start date

1/14/2025

Estimated completion

3/1/2028

Countries

Spain

Related genes

Locations

• Barcelona, Spain

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Histologically confirmed diagnosis of non-metastatic breast cancer: stages cT1-T4, cN0-N3, M0, and candidates for neoadjuvant chemotherapy (NAC).
* Age ≥ 18 years.
* Signed informed consent.

Exclusion Criteria:

* Contraindication or physical inability to perform moderate-to-high intensity physical exercise.
* Pregnant or breastfeeding patients.
* Presence of other active synchronous neoplasms.
* Metastatic breast cancer (stage IV).
* Patients already engaging in regular physical exercise: more than 150 minutes of moderate or intense aerobic exercise per week.
* Male breast cancer patients.
* Personal history of a previous malignancy treated with chemotherapy.
* Severe or poorly controlled psychiatric illness (including uncontrolled active substance abuse).