This study aims to incorporate biomarkers into clinical assessments to understand how bipolar disorder progresses across stages; it collects psychometric clinical assessments, biological samples, and neuroimaging data. It enrolls men and women aged 18 to 70 with bipolar-spectrum manifestations. It is a study with no assigned phase and is not currently recruiting but is still ongoing.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: 1. A range of bipolar spectrum manifestations meeting the criteria of the Kupka \& Hillegers' staging model 2. Both genders 3. Age ≥18 and ≤70 years 4. Written informed consent obtained Exclusion Criteria: 1. Inability to provide informed consent 2. Diagnosis of intellectual disability 3. Presence of a severe medical condition (e.g., previously diagnosed neurological disorders, including chronic migraine, hematological diseases, renal disorders, history of stroke, or diabetes mellitus, even if compensated; controlled hypertension allowed) 4. Current substance use disorder or within six months prior to screening