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This study aims to identify the genome variants underlying non-obstructive azoospermia (NOA) or primary ovarian insufficiency (POI), conditions that can cause infertility. Adult men and women of reproductive age with a clinical diagnosis of NOA, oligospermia, or POI can take part. It is a study without an assigned phase and is currently recruiting participants.
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Adult male or female, of reproductive age 4. Clinical diagnosis of NOA, oligospermia, or POI. 5. In good general health with no medical history suspected as the cause of infertility. EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Current use of medications that may cause infertility (chemotherapy, etc.) 2. Pregnant or lactating 3. Medical history indicating known common cause of infertility such as karyotype anomalies, Y-chromosome microdeletions, known monogenic causes, or other medical history affecting gamete production (i.e. injuries, surgical operations, infections, radiation, or chemotherapy).