This study evaluates, at the clinical and radiological level, the relationship between genetic polymorphisms (single nucleotide polymorphisms) and the healing of periapical lesions at the tip of the tooth root in people with chronic apical periodontitis. Patients aged 18 to 65 with non-vital lower jaw molar teeth showing asymptomatic apical periodontitis and no genetic disorders may take part. It is a study without a phase and is currently not recruiting but ongoing (active, not recruiting).
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Patients aged between 18 and 65 years * Devital mandibular molar teeth with asymptomatic apical periodontitis * Teeth showing negative response to percussion and palpation tests * Teeth with negative responses to cold test and electric pulp testing * Teeth with a Periapical Index (PAI) score of 3 or 4 * Patients classified as ASA I * Patients without any genetic disorders (e.g., Down syndrome, congenital insensitivity to pain, etc.) Exclusion Criteria: * Teeth with internal or external resorption * Teeth with a history of trauma * Teeth with vertical or horizontal root fractures * Teeth with grade 3 mobility and loss of function * Teeth that cannot be isolated with rubber dam or are not restorable * Pregnant women or patients with suspected pregnancy * Root canal curvature greater than 25° according to Schilder's classification * Patients with generalized periodontitis * Presence of periodontal pocket depth greater than 3 mm in the involved tooth * Patients classified as ASA II or higher * Presence of preoperative swelling, sinus tract, or pain on palpation * Patients with bruxism * Teeth with suspected periodontal-endodontic lesions * Teeth with a PAI index below 2 or above 5