Modulation of Periapical Inflammation Following Nano-sized Intracanal Medication. A Randomized Controlled Clinical Trial

Plain-language summary

This study looks at how nano-sized root canal medications affect inflammation around the tooth root (periapical inflammation). It evaluates pastes such as nanochitosan paste and nano-calcium hydroxide paste, and can include patients with single-rooted, symptom-free teeth that have had a previously failed root canal treatment. It is a study without an assigned phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Recruiting

Sponsor

Al-Azhar University

Intervention

Nanochitosan paste, Nano-calcium hydroxide paste, Calcium hydroxide paste

Start date

2/1/2026

Estimated completion

1/30/2027

Countries

Egypt

Related genes

Locations

• Cairo, Egypt

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

Patients have single rooted teeth with root canal form type I. Have previous endodontic therapy with failure. Have periapical radiolucency (PAI score of 3 or 4). Asymptomatic patients who had no pain or swelling, had a negative response to palpation and percussion.

Exclusion Criteria:

Patients who had received antibiotic therapy within the past 3 months. Pregnancy and lactation. Systemic disease. Physical or mental disability. Non-restorable teeth. Any signs of resorption, immature roots, fracture, sinus tract and dental anomaly