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The Influence of Daily Intake of Whole Grain Barley or Oats on Biomarkers of Cardiovascular Disease
Bu çalışma, günlük olarak tam tahıl arpa veya yulaf tüketmenin kalp-damar hastalığı (cardiovascular disease) ile ilişkili biyobelirteçler üzerindeki etkisini incelemektedir. Çalışmaya, 25-70 yaş arası, vücut kitle indeksi 19-38 arasında olan kadın ve erkekler dahil edilmiştir. Faz uygulanmayan bir çalışma olarak yürütülmüş ve tamamlanmıştır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: * Men and women between the ages of 25-70 years * Body mass index (BMI) ≥ 19 and ≤ 38 * Willingness and ability to make scheduled appointments at clinical site as required by study protocol Exclusion Criteria: * Do not regularly consume breakfast or dislike cereal for breakfast * Known (self-reported) allergy or adverse reaction to grains (e.g., wheat, gluten, barley) * Presence of kidney disease, liver disease, gout, untreated or unstable hypothyroidism, untreated or unstable hyperthyroidism, certain cancers, gastrointestinal disease, pancreatic disease, other metabolic diseases, or malabsorption syndromes * Type 2 diabetes requiring the use of oral antidiabetic agents or insulin * Fasting triglycerides \> 300 mg/dL * Fasting glucose \> 126 mg/dL * Use of cholesterol lowering medication * Blood pressure \> 180/100 or hypertension treated with calcium channel blockers, direct acting vasodilators, or beta blockers * History of bariatric or certain other surgeries related to weight control * History of major surgery within 3 months of enrollment * Smokers or other tobacco users (during 6 months prior to the start of the study) * Antibiotic use during the intervention or for 3 months prior to the intervention period * History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets) * Volunteers who have lost 10% of body weight within the last 6 months * Unable or unwilling to give informed consent or communicate with study staff * Self-report of alcohol or substance abuse within the past 12 months and/or current acute treatment or rehabilitation program for these problems (long-term participation in Alcoholics Anonymous is not an exclusion) * Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol