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Regulation of Cervical Mucus Secretion
Bu çalışma, hormonların servikal mukus (cervical mucus) salgısını nasıl düzenlediğini araştırmaktadır. Katılımcılara Leuprolide asetat ile östrojen, progesteron ve progestin hormon tedavileri uygulanmıştır. Çalışmaya 21-40 yaş arası, düzenli adet döngüsüne sahip sağlıklı kadınlar katılabilmiştir. Çalışma Faz 4 aşamasında yürütülmüş ve tamamlanmıştır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: * Normal menstrual cycles of 25-35 days in length for at least previous 3 cycles * 21-40 years of age * BMI \>18, \<30 * Serum P4 ≥ 3 ng/ml on single sample collected between days 18-25 of self-reported menstrual cycle * Flexible schedule allowing morning blood draws on less than 48 hour notice * In good general health * Commit to remain on stable diet during study period (no changes to normal dietary habits) * Commit to using non-hormonal contraceptive methods during study period except those prescribed in the experimental protocol * No objections to taking study drugs * No objections to refraining from intercourse the night before any sampling and willing to using condoms during vaginal intercourse. Exclusion Criteria: * Oral contraceptive use or other hormone supplement within the preceding 2 months * Women with current cervical infection * Evidence of abnormal cervical cytology * Use of Paragard IUD for contraception * Long-acting hormonal contraceptive use in the past 12 months (e.g., Depo-Provera®) * Contraindications to study drugs * Current or past pregnancy within the previous 6 months or currently trying to conceive * Desiring to conceive in the next 8 months * Breastfeeding in the past 2 months * Diagnosed Diabetes or Metabolic Syndrome * Current or previous use of cholesterol lowering drugs within the preceding 12 months * Diagnosed Polycystic Ovary Syndrome * History of, or self-reported, substance abuse * Smoker * Previous infertility treatment excluding male factor issues * Use of an investigational drug within the past 2 months * History of excisional or ablative treatment procedure on cervix (ie. LEEP, Cryotherapy, Cold Knife Cone)