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Umbrella Trial of Subtype-Targeted Therapies in ER+/HER2- Breast Cancer
Bu çalışma, hormon reseptörü pozitif (ER+) ve HER2 negatif meme kanseri (breast cancer) olan hastalarda, tümörün alt tipine göre seçilen Alpelisib, Tamoxifen, Zotatifin ve Fulvestrant gibi hedefe yönelik tedavileri değerlendirmiştir. Çalışmaya, tümörü henüz ameliyatla çıkarılmamış, 18 yaş ve üzeri kadın ve erkek hastalar alınmıştır. Çalışma Faz 2 aşamasında yürütülmüş ve tamamlanmıştır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: * Pre-Screening Phase * Biopsy-proven ER-positive, HER2-negative breast cancer. ER-positivity and PR-positivity are defined as ≥1% cells staining positive by immunohistochemistry. HER2-negativity is defined by IHC or FISH, per ASCO-CAP 2018 guidelines. Breast tumor must be intact and tumor size must be ≥ 1 cm as measured by ultrasound, mammogram, MRI, or clinical exam. If tumor is locally recurrent, it must be in the breast (not skin, node, or chest wall recurrence). Ki67 may or may not have been done locally but if done locally, must be ≥ 5%. Any nodal status is allowed, as M0 or M1 disease. * Women or men, age ≥ 18 years old. * Performance status 0 to 1 (by Eastern Cooperative Oncology Group \[ECOG\] scale). * Ability to understand and the willingness to sign a written informed consent document. Treatment Phase * Breast tumor classifies as relevant integrative subtype per tumor sequencing performed and analyzed by central laboratory. * Breast tumor Ki67 score ≥ 10% as assessed by central laboratory. * Each investigational agent specific inclusion criteria can be found in the agent-specific appendix Exclusion Criteria: * Pregnant woman, as confirmed by positive serum hCG test prior to initiating study treatment. Nursing (lactating) woman also not allowed. * Prior breast cancer-directed therapy (surgery, radiation, chemotherapy, or endocrine therapy) is not allowed, with the exception of people with in-breast recurrences. People with in-breast recurrences cannot have had breast cancer-directed therapy (radiation, chemotherapy, or endocrine therapy; surgery is acceptable) within the 6 months prior to signing the pre-screening consent. Pre-endocrine therapy for breast cancer risk reduction is allowed. * Known hypersensitivity to study agent (IP) or standard endocrine therapy drug, or to any of the excipients of study agent (IP) or standard endocrine therapy drug. * Each study agent specific exclusion criteria can be found in the agent-specific appendix