Yetişkin Erkeklerde Alkol Kullanım Bozukluğunun Tedavisinde Probiyotiklerin Etkililiği

Sade dilde özet

Bu çalışma, alkol kullanım bozukluğu (alcohol use disorder) olan yetişkin erkeklerde Lactobacillus içeren bir probiyotiğin, plasebo ile karşılaştırılarak etkisini incelemiştir. Çalışmaya, DSM-5 ölçütlerine göre tanı konmuş, 18-55 yaş arası erkek hastalar alınmıştır. Çalışma faz uygulanmayan bir çalışma olarak yürütülmüş ve tamamlanmıştır.

Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.

Deney bilgileri

Faz

Faz dışı

Durum

Tamamlandı

Sponsor

Universiti Sains Malaysia

Müdahale

Lactobacillus sp. probiotic, Placebo

Başlangıç

01.06.2022

Tahmini bitiş

30.06.2024

Ülkeler

China

İlgili genler

Merkezler

• Xinxiang, China

Uygunluk kriterleri

Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.

Inclusion Criteria (AUD patients):

* Hospitalized patients diagnosed with untreated alcohol use disorder (confirmed by the diagnostic criteria of DSM-5).
* Male, age 18 to 55 years old, Han nationality, junior high school education or above, right-handed.
* Those with normal eyesight, including corrected vision(screened clinically).

Exclusion Criteria (AUD patients):

* The patient suffer from other mental illnesses (screen by DSM-V criteria).
* The patient has allergy reaction to medications use for conventional treatment of alcohol use disorder.
* The patient had a history of organic brain disease, a pacemaker, gastrointestinal surgery, or serious health problems.
* The patient had a history of seizures.
* The patient is complicated with severe physical disease.
* Patient has other drug dependence (except for nicotine dependence).
* The patient took drugs affecting intestinal flora 30 days before and during admission.
* The patient has participated in any other alcohol-related studies or trials within the past 30 days.
* Patients had use any prescription or over-the-counter drugs in the past 30 days that may affect mood or alcohol cravings.

Inclusion Criteria (controls):

* Male, age 18 to 55 years old, Han nationality, junior high school education or above, right-handed.
* No history of psychoactive substance abuse, except tobacco (screen with urine dipstick test).
* Those with normal eyesight, including corrected vision (screen clinically).
* No alcoholic beverages in the last 2 weeks.
* According to the WHO healthy alcohol consumption standard, the average intake of pure alcohol per week is less than 210 grams, or do not drink at all (screen clinically).

Exclusion Criteria (controls):

* Those who suffer from other mental illnesses (screen by DSM-V criteria).
* Those who has history of organic brain disease, a pacemaker, gastrointestinal surgery, or serious health problems.
* Those who has history of seizures.
* Those complicated with severe physical disease.
* Those with drug dependence, including alcohol dependence (exception for nicotine dependence).
* Those who took drugs affecting intestinal flora 30 days before and during admission.
* Those who has participated in any other alcohol-related studies or trials within the past 30 days.
* Those who use any prescription or over-the-counter drugs in the past 30 days that may affect mood or alcohol cravings.