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IPGx PILOT Whole Genome Sequencing Extension Cohort
Bu çalışma, tüm genom dizileme (whole genome sequencing) yöntemiyle ilaçların kişiye göre etkisini araştıran bir farmakogenomik çalışmadır. Çalışmaya, reçeteli veya reçetesiz en az 5 ilaç ya da takviye kullanan, 18-100 yaş arasındaki kişiler katılabiliyor. Faz uygulanmayan bir çalışma olup halen katılımcı almaktadır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: * Individuals taking 5 or more medications, including over the counter drugs, supplements, natural products, cannabis produces, or other recreational drugs. * Ability to give and comprehend the consent process. * Consent to donate urine samples, genetic data through buccal swabs and blood samples, and undergo a comprehensive history and physical examination. * All genders * Age 18-100 Exclusion Criteria: * Subject has been diagnosed or is being treated for any cancer other than basal cell cancer in the last 5 years. Patients with metastatic melanoma in the last 5 years will be excluded. * Admitted to hospice. * Patient has ever been diagnosed with Hepatitis B or C. * Patient has ever been diagnosed with active liver disease, hepatomegaly, grossly abnormal liver function. Meld score \>10, ALT, or AST \>100U/L or an AST/ALT ratio \>2 * Patients taking imidazole antifungal medication. * Declines to participate or interact with staff/share their medical status. * A diagnosis of Alzheimer's disease or related dementias in a medical record indicates a progressive, debilitating condition that impairs memory, thought processes, and functioning. * Pregnant patients will be excluded. * Individuals who are unable or unwilling to provide consent will be excluded. * Unable to verbally communicate and comprehend English language.