Nazofarenks Kanserinde APOE Gen Polimorfizminin Kan-Beyin Bariyeri Geçirgenliğini Düzenlemesi ve Radyoterapi Sonrası Bilişsel İşlev Üzerindeki Etkisi: Bir MRG Çalışması

Sade dilde özet

Bu çalışma, nazofarenks kanseri (nasopharyngeal carcinoma) hastalarında APOE gen polimorfizminin kan-beyin bariyeri geçirgenliği ve radyoterapi sonrası bilişsel işlev üzerindeki etkisini MRG (manyetik rezonans görüntüleme) yöntemiyle incelemektedir. Çalışmaya; yeni tanı almış, 20-60 yaş arası, uzak metastazı bulunmayan ve yoğunluk ayarlı radyoterapi (IMRT) planlanan hastalar alınmıştır. Sun Yat-sen University tarafından yürütülen faz uygulanmayan çalışma; şu an katılımcı almamakta ancak devam etmektedir (active, not recruiting).

Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.

Deney bilgileri

Faz

N/A

Durum

Devam ediyor, katılım kapalı

Sponsor

Sun Yat-sen University

Müdahale

Using DCE-MRI, fMRI, and DSI, establish a longitudinal brain functional and structural imaging database for three groups of nasopharyngeal carcinoma patients before and 18 months after radiotherapy.

Başlangıç

01.01.2024

Tahmini bitiş

31.12.2026

Ülkeler

China

İlgili genler

Merkezler

• Guangzhou, China

Uygunluk kriterleri

Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.

Inclusion Criteria:

Patients newly diagnosed with nasopharyngeal carcinoma, pathologically confirmed, and who have not received anti - tumor treatments such as surgery, induction chemotherapy, or radiotherapy.

All patients are of Han ethnicity and right - handed. Patients are aged between 20 and 60 years old, with an educational level of junior high school or above.

The clinical stage of the included patients is AJCC 8th edition stage I - IVa, without distant metastasis, and patients are scheduled to receive intensity - modulated radiotherapy (IMRT) according to the clinical plan.

Patients have no other serious systemic diseases except nasopharyngeal carcinoma.

There is no intracranial invasion of nasopharyngeal carcinoma. Routine MRI examinations (including T1WI, T2WI, and FLAIR) are negative. The baseline basic cognitive assessment scales (MoCA and MMSE) before radiotherapy are normal.

Patients have no family history of mental illness. Patients have no history of neurological diseases or head trauma. After fully understanding the experimental content, the subjects agree to participate in this project and sign the informed consent form

Exclusion Criteria:

Patients diagnosed with Alzheimer's disease (AD) before being included. AD is diagnosed by psychiatrists according to the 9th Revision of the International Classification of Diseases, Clinical Modification (ICD - 9 - CM).

Patients with intracranial lesions detected by routine MRI examinations. Patients with contraindications to magnetic resonance examinations. Patients with concurrent other diseases. Patients with tumor recurrence who need re - radiotherapy, or those who cannot adhere to and complete IMRT treatment.

Left - handed or ambidextrous patients. Patients with a history of head trauma or mental/neurological diseases. Patients aged less than 20 or more than 60 years old. Patients with serious systemic diseases such as heart, lung, or kidney diseases.

Patients with diabetes or hypertension. Patients who cannot cooperate to complete the neurocognitive scale tests.