Hereditary Parkinson s Disease Natural History Protocol

Plain-language summary

This observational study aims to follow and understand the natural history of hereditary (early-onset) Parkinson's disease. People aged 18 to 80 with a history of early-onset Parkinson's disease, along with healthy volunteers and family members, may take part. It was carried out as an observational study with no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Completed

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Start date

7/8/2015

Estimated completion

8/15/2017

Countries

United States

Related genes

Locations

• Bethesda, United States

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

* INCLUSION CRITERIA

Parkinson's Subjects

\- Age 18 years to 80 years old with a history of early onset Parkinson's disease or Parkinsonism (Presentation within the first five decades of life).

Healthy Control Subjects

\- Age 18 years to 80 years old with no history or family history of Parkinson's disease or Parkinsonism.

Family Member Control Subjects

-Family members, of enrolled EOPD subjects, who themselves do not have Parkinson's disease or Parkinsonism can be enrolled as controls on this study.

All Subjects

* Willingness and legal ability to give and sign informed study consent
* Willingness to have blood or tissue samples studied, and potentially stored for future research

EXCLUSION CRITERIA

All Subjects

* Subjects who are unable or unwilling to sign an informed consent
* Subjects with genetic defects associated with diseases including other neurologic syndromes.
* Pregnancy