Dietary Intervention and BRCA Penetrance

Plain-language summary

This study examines whether a change in diet affects how often inherited BRCA gene mutations lead to breast cancer in women who carry them. It was open to women aged 18 to 70 who carry a BRCA mutation and are either healthy or have breast cancer without metastases. It was conducted as a study with no assigned phase and has been completed.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Completed

Sponsor

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Intervention

Dietary intervention

Start date

12/1/2015

Estimated completion

12/31/2018

Countries

Italy

Related genes

Locations

• Milan, Italy

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Eligible study subjects are women, aged 18-70, either unaffected or affected with BC, without metastases or previous ovarian cancer, who underwent genetic counselling and fulfilled high-risk selection criteria for genetic testing based on personal and/or family history and resulted carriers of deleterious BRCA mutations.

Exclusion Criteria:

* Unaffected BRCA mutation carriers with bilateral prophylactic mastectomy are not included in the cohort or are censored at the time of surgery.