Genes Associated With Bone Metabolism in the Saliva During Orthodontic Treatment

Plain-language summary

This study examines the expression of genes associated with bone metabolism in saliva during orthodontic treatment, using PCR. It enrolls generally healthy individuals aged 15 to 25 with moderate dental crowding. This is a study with no assigned phase; it is not currently recruiting but is ongoing (active, not recruiting).

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Active, not recruiting

Sponsor

Kurdistan Higher Council of Medical Specialties

Intervention

PCR

Start date

10/12/2025

Estimated completion

2/1/2026

Countries

Iraq

Related genes

Locations

• Erbil, Iraq

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion criteria:

1.15 to 25 years of age 2.moderate crowding (3-6 mm) 3.generally good health with no systemic conditions that could influence bone metabolism 4. no recent use of medications known to affect bone metabolism (such as bisphosphonates and corticosteroids) or any other NSAIDs.

Exclusion criteria:

1. periodontal disease
2. smoking or any form of tobacco use
3. pregnancy or lactation
4. prior orthodontic treatment
5. craniofacial syndromes
6. The use of antibiotics within 3 months before the study. -