The Signature of Alzheimer's Disease in Subjective Cognitive Decline

Plain-language summary

This observational study explores the early signs and signature of Alzheimer's disease in people experiencing subjective cognitive decline. People who meet the criteria for subjective cognitive decline, have normal daily functioning, and score adequately on a cognitive examination can take part. It is a study without an assigned phase and is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

IRCCS Policlinico S. Donato

Start date

10/1/2025

Estimated completion

3/1/2028

Countries

Italy

Related genes

Locations

• San Donato Milanese, Italy

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Clinical diagnosis of SCD according to the SCD-I criteria;
* Mini-Mental State Examination (MMSE) score greater than 24, adjusted for age and education level;
* Normal functioning on the Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) scales.

Exclusion Criteria:

* History of head trauma;
* Current neurological and/or systemic diseases;
* Symptoms of psychosis, major depression, or substance use disorder.