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Garlic Intake And Biomarkers Of Cancer Risk
Bu çalışma, sarımsak tüketiminin kanser riskiyle (cancer risk) ilişkili biyobelirteçler üzerindeki etkisini, sarımsak alan ve almayan gruplar karşılaştırılarak incelemektedir. Çalışmaya, 40-80 yaş arası, belirli sağlık ölçütlerini karşılayan sağlıklı bireyler dahil edilmiştir. Faz uygulanmayan bir çalışma olarak yürütülmüş ve tamamlanmıştır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: * Age 40-80 years Exclusion Criteria: * Younger than 40 years old or older than 80 years old * Use of blood-thinning medications such as Coumadin (warfarin), Dicumarol (dicumarol), or Miradon (anisinidione) * Presence of kidney disease, liver disease, gout, certain cancers, thyroid disease, gastrointestinal, other metabolic diseases or malabsorption syndromes. * Have been pregnant during the previous 12 months, are currently pregnant or lactating, or plan to become pregnant during the study * Follicle stimulating hormone levels above 35 mIU/mL serum * Type 2 diabetes requiring the use of oral antidiabetic agents or insulin * History of eating disorders or other dietary patterns which are not consistent with the dietary intervention (e.g., vegetarians, very low fat diets, high protein diets) * Use of prescription or over-the-counter antiobesity medications or supplements (e.g., phenylpropanalamine, ephedrine, caffeine) during and for at least 6 months prior to the start of the study or a history of a surgical intervention for obesity * Active cardiovascular disease (such as a heart attack or procedure within the past three months or participation in a cardiac rehabilitation program within the last three months, stroke, or history/treatment for transient ischemic attacks in the past three months, or documented history of pulmonary embolus in the past six months). * Use of any tobacco products in past 6 months * Use of oral or IV antibiotics during the month preceding the study or during the study * Unwillingness to abstain from vitamin, mineral, and herbal supplements for two weeks prior to the study and during the study * Known (self-reported) allergy or adverse reaction to garlic * Inability to metabolize garlic * Unable or unwilling to give informed consent or communicate with study staff * Self-report of alcohol or substance abuse within the past twelve months and/or current acute treatment or rehabilitation program for these problems (Long-term participation in Alcoholics Anonymous is not an exclusion) * Other medical, psychiatric, or behavioral factors that in the judgment of the Principal Investigator may interfere with study participation or the ability to follow the intervention protocol