Hastalığın ve Tedaviye Yanıtın Erken Belirteçleri

Sade dilde özet

Bu çalışma, yeni tanı almış tip 1 diyabet (type 1 diabetes) hastalarında hastalık ve tedaviye yanıtın erken belirteçlerini araştırmak amacıyla Abatacept ilacını incelemektedir. Çalışmaya, tanısından itibaren yaklaşık 7 aya kadar süre geçmiş, 6-55 yaş aralığındaki kişiler alınmıştır. Çalışma Erken Faz 1 aşamasında yürütülmüş ve tamamlanmıştır.

Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.

Deney bilgileri

Faz

Erken Faz 1 (Early Phase 1)

Durum

Tamamlandı

Sponsor

Sandra Lord, MD

Müdahale

Abatacept

Başlangıç

05.03.2021

Tahmini bitiş

24.05.2024

Ülkeler

United States

İlgili genler

Merkezler

• Seattle, United States
• Milwaukee, United States

Uygunluk kriterleri

Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.

Inclusion Criteria:

1. ≤ 7 months from type 1 diabetes diagnosis based on ADA criteria
2. \> 21 days from type 1 diabetes diagnosis or metabolically stable per study physician assessment
3. Males and females 6-55 years of age, inclusive, at time of screening visit
4. Peak MMTT stimulated C-peptide ≥ 0.2 pmol/ml
5. Females of child-bearing age must be willing to use effective birth control for 1 year (which may include abstinence) from screening visit and undergo regular pregnancy testing
6. Up to date for clinically recommended immunizations prior to screening
7. Willing to forgo live vaccines 3 months prior to the screening visit until three months following last study drug administration
8. Willing and able to give informed consent or have parent or legal guardian provide informed consent if the subject is \< 18 years of age
9. Weight ≥ 20 kg at baseline visit
10. HbA1c ≤ 8.5% at baseline visit
11. Positive for at least 1 diabetes autoantibody (excluding mIAA in those who have received ≥ 2 weeks of exogenous insulin therapy)

Exclusion Criteria:

1. Concurrent or recent (within the past 30 days of screening MMTT (visit -1)) use of non-insulin therapies aimed to control hyperglycemia
2. Females who are pregnant or lactating
3. Immunodeficiency or clinically significant chronic lymphopenia
4. Have an active infection at time of screening or baseline visit
5. Recent exposure, or possible or known active SARS-CoV-2 infection as defined by public health guidelines
6. Positive QuantiFERON or PPD TB test, history of tuberculosis, or active TB infection
7. Active infection with EBV or CMV, defined by real-time PCR
8. History of other clinically significant autoimmune disease needing chronic therapy with biologics or steroids with the exception of celiac disease and stable thyroid disease
9. Require use of other immunosuppressive agents for any other condition
10. Use of medications known to influence glucose tolerance
11. Have any complicating medical or psychological issues or abnormal clinical laboratory results that interfere with study conduct or cause increased risk. These include pre-existing cardiac disease, COPD, neurological, or clinically significant blood count abnormalities (such as lymphopenia, leukopenia, or thrombocytopenia).
12. Have serologic evidence of current or past HIV, Hepatitis B (positive for Hepatitis B core antibody or surface antigen), or Hepatitis C infection.
13. Have a history of malignancies
14. Receipt of live vaccine (MMR, intranasal influenza, varicella, rotatvirus) in 3 months before treatment