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Phase 2 Combination Study With Escalating Doses of MS1819-SD on Top of a Stable Dose of PPEs
Bu çalışma, kistik fibrozis (cystic fibrosis) ve pankreas yetmezliği olan hastalarda, mevcut pankreas enzim tedavisine ek olarak artan dozlarda MS1819-SD adlı ilacı değerlendirdi. Katılım için 12 yaş üzeri, stabil enzim tedavisi alan ve tanı kriterlerini karşılayan hastalar aranıyordu. Çalışma Faz 2 aşamasında yürütülmüş ve tamamlanmıştır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: 1. Signed and dated informed consent form. 2. Age \> 12 years at the time of screening 3. Male or female. 4. Under stable dose of PPE ≥ 1 month. Stable dose is defined as dose of medication not changed during this time period and the medication must be commercially available and be administered in the recommended dose range. 5. A nutritional status as defined by: 1. BMI ≤ 22.0 kg/m2 for female patients 2. BMI ≤ 23.0 kg/m2 for male patients 3. BMI ≤ 50th percentile for patients 12 to \< 18 years of age. 6. Cystic fibrosis, based on 2 clinical features consistent with CF in the opinion of the investigator AND sweat chloride concentration \> 60 mmol/L by pilocarpine iontophoresis. 7. Faecal pancreatic elastase-1 \< 100 µg/g of stools at screening. 8. Baseline CFA \< 80% with a maximum daily dose of 10,000 lipase units/kg/day. 9. Clinically stable with no documented evidence of significant respiratory symptoms that would require administration of intravenous antibiotics, oxygen supplementation, or hospitalization within the 30 days of screening. 10. Male and female patients, if of childbearing potential, must use a reliable method of contraception during the study. A reliable method of birth control is defined as one of the following: oral or injectable contraceptives, intrauterine device, contraceptive implants, tubal ligation, hysterectomy, or a double-barrier method (diaphragm with spermicidal foam or jelly, or a condom), abstinence or vasectomy. Periodic abstinence (calendar, symptothermal, or post-ovulation methods) is not an acceptable method of contraception. The preferred and usual lifestyle of the patient must also be evaluated in determining if sexual abstinence is a reliable method of birth control. 11. Be considered as reliable and capable of adhering to the protocol, according to the judgment of the investigator. Exclusion Criteria: 1. Established or suspected fibrosing colonopathy. 2. Total or partial gastrectomy. 3. A history of solid organ transplant or significant surgical resection of the bowel; significant resection of the bowel is defined as any resection of the terminal ileum or ileocecal valve. Patients who have had qualitative, long-term changes in nutritional status after any other bowel resection (eg, increased of new need for pancreatic enzyme supplementation compared with preoperative status to maintain the same nutritional status) should also be excluded. 4. Any chronic diarrheal illness unrelated to pancreatic insufficiency (eg, infectious gastroenteritis, sprue, inflammatory bowel disease) 5. Known hypersensitivity or other severe reaction to any ingredient of the investigational medicinal product (IMP). 6. Bilirubin \> 1.5 times upper limit normal (ULN). 7. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> 5 times ULN. 8. Alkaline phosphatase (ALP) \> 5 times ULN. 9. Gamma glutamyltransferase (GGT) \> 5 times ULN. 10. Signs and/or symtoms of liver cirrhosis or portal hypertension (eg, splenomegaly, ascites, esophageal varices), or documented liver disease unrelated to CF 11. Patients with a known allergy to the stool marker. 12. Feeding via an enteral tube during 6 months before screening 13. Routine use of anti-diarrheals, anti-spasmodics, or cathartic laxatives, or a change in chronic osmotic laxatives (eg, polyethylene glycol) regimen in the previous laxative therapy within the last 12 months before screening 14. History of severe constipation with \< 1 evacuation/week under appropriate laxative therapy within the last 12 months before screening. 15. Documentation of distal intestinal pseudo-obstruction syndrome within the last 12 months before screening. 16. Forced Expiratory Volume ≤ 30% at the screening visit. 17. Lactation or known pregnancy or positive pregnancy test at both screening and baseline for women of childbearing potential. 18. Participation in another clinical study involving an IMP within 30 days before inclusion or concomitantly with this study. 19. Poorly controlled diabetes according the investigator's judgement.