Diyabetik Ayak Ülseri Olan Hastalarda ON101 Kreminin Etki Mekanizmasını Araştıran Randomize, Çift Kör, Plasebo Kontrollü Klinik Çalışma

Sade dilde özet

Bu çalışma, diyabetik ayak ülseri (diabetic foot ulcer) olan hastalarda ON101 kreminin etki mekanizmasını plasebo ile karşılaştırarak araştırmaktadır. Tip 1 ya da Tip 2 diyabeti olan, belirli boyut ve derecede en az bir ayak ülseri bulunan, 20-80 yaş arası hastalar katılabilmektedir. Çalışma faz uygulanmayan bir araştırma olarak yürütülmüş ve tamamlanmıştır.

Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.

Deney bilgileri

Faz

Faz dışı

Durum

Tamamlandı

Sponsor

Oneness Biotech Co., Ltd.

Müdahale

ON101 Cream, Placebo

Başlangıç

23.02.2021

Tahmini bitiş

24.12.2021

Ülkeler

Taiwan

İlgili genler

Merkezler

• Taipei, Taiwan

Uygunluk kriterleri

Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.

Inclusion Criteria:

1. Subjects, male or female, aged 20 to 80 years (inclusive) with Type 1 or Type 2 diabetes undergoing therapy for glycemic control.
2. Subjects has a glycosylated hemoglobin, HbA1c \< 12%.
3. Presence of at least one diabetic foot ulcer that meets all of the following criteria:

   1. At the time of Visit 0 (V0), the ulcer has existed for at least one month;
   2. At the time of Visit 1 (V1), the post-debridement ulcer presents Grade 2 or Grade 3 (without osteomyelitis or active infection) in Wagner Ulcer Classification System assessment; and
   3. Area should be ≥ 4 cm2 and ≤ 25 cm2;
   4. No higher than the ankle.
4. Subject has adequate vascular perfusion of the affected limb, confirmed by Ankle-Brachial Index (ABI) ≥ 0.8 and ≤ 1.3.
5. Clinically normal resting ECG at the first Screening Visit (V0) or, if abnormal, considered to be not clinically significant by the Investigator.
6. Subject must use an off-loading method for the target ulcer on the plantar during the whole study period.
7. Subject, if female of child-bearing potential, has a negative pregnancy test on urine at screening, must not be breastfeeding, and willing to use two medically accepted methods of contraception (e.g., barrier contraceptives \[female condom or diaphragm with a spermicidal gel\], hormonal contraceptives \[implants, injectables, combination oral contraceptives, transdermal patches, or contraceptives rings\], and intrauterine devices) during the course of the study (excluding women who are not of childbearing potential and/or who have been sterilized).
8. Subject is able and willing to comply with the study procedures.
9. A signed and dated informed consent form has been obtained from the subject.

Exclusion Criteria:

1. In response to standard of care (SoC), ulcer size reduction is ≥20% during the two-week run-in screening period (between the first Screening Visit/V0 and Baseline Visit/V1).
2. Ulcers with exposed bone or associated with osteomyelitis. Note: The osteomyelitis should be ruled out by clinical examination (probing of the wound) or X-ray findings where find necessary by the Investigator.
3. Presence of necrosis, purulence, or sinus tracts that cannot be removed by debridement.
4. Laboratory values at Screening of:

   1. Liver function test (total bilirubin, aspartate aminotransferase \[AST\], or alanine transaminase \[ALT\]) \> 3x the upper limit of normal, or
   2. Albumin \< 2.5 g/dL, or
   3. Renal function test (serum creatinine or urea) \> 2x the upper limit of normal
5. Presence of any clinically significant medical condition(s) in medical history during screening period that, in the opinion of the Investigator, could interfere with wound healing, including but not limited to the following:

   1. Acute or unstable Charcot foot
   2. Current sepsis
   3. Active malignant disease. A subject, who has had a malignant disease in the past, was treated and is currently disease-free, maybe considered for study entry.
   4. Acquired immune deficiency syndrome (AIDS) or HIV positive
6. Subject is currently receiving (i.e., within 30 days of randomization visit) or scheduled to receive any of the following medication or therapies, could interfere with wound healing during the course of the study:

   1. Immunosuppressive or chemotherapeutic agents, radiotherapy, or systemic corticosteroids
   2. Autoimmune disease therapy
   3. Lower limb revascularization surgery (e.g., angioplasty, artery bypass surgery)
   4. Hyperbaric oxygen therapy
   5. Bioengineered tissue or skin substitutes
   6. Use of any investigational drug(s)
   7. Cell therapy
7. More than two (2) ulcers located on or below the malleoli on the target foot.
8. A psychiatric condition (e.g., suicidal ideation), current or chronic alcohol or drug abuse problem, determined from the subject's medical history, which in the opinion of the Investigator, may pose a threat to subject compliance.
9. Has any other factor which may, in the opinion of the Investigator, compromise participation and/or follow-up in the study.
10. Body mass index (BMI) \>40 with plantar ulcer.
11. Heavy smoker (\>1 pack per day).