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4D-710 in Adult Patients With Cystic Fibrosis
Bu Faz 1/2 (Phase 1/2) çalışma, kistik fibroz (cystic fibrosis, CF) olan yetişkinlerde araştırma aşamasındaki 4D-710 gen terapisinin tek doz olarak uygulandığı, çok merkezli ve açık etiketli bir araştırmadır. Katılım için 18 yaş ve üzeri olmak ve akciğer tutulumu ile birlikte doğrulanmış kistik fibroz tanısı bulunmak gerekmektedir. Tanı ölçütleri arasında ter klorür değerinin 60 mmol/L ve üzerinde olması ile CFTR geninde iki alelli mutasyon ya da tek mutasyonla birlikte klinik CF bulguları yer almaktadır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Key Inclusion Criteria (Primary Study):
1. 18 years and older
2. Confirmed diagnosis of cystic fibrosis (CF) and CF lung disease including:
1. Sweat chloride ≥ 60 mmol/L
2. Mutation Status
* Bi-allelic mutations in the CFTR gene, or
* Single mutation in the CFTR gene and clinical manifestations of CF lung disease
3. Ineligible for CFTR modulator therapy, or previously received modulator therapy but discontinued due to adverse effects.
3. Forced expiratory volume in 1 second (FEV1) ≥ 50% and ≤ 90% of predicted (per Global Lung Function Initiative) at Screening
4. Resting oxygen saturation ≥ 92% on room air at Screening
Key Inclusion Criteria (Sub-Study):
1. 18 years and older
2. Confirmed diagnosis of cystic fibrosis (CF) and CF lung disease including:
1. Sweat chloride ≥ 60 mmol/L
2. Mutation Status
* Bi-allelic mutations in the CFTR gene, or
* Single mutation in the CFTR gene and clinical manifestations of CF lung disease
3. Currently on a stable dose of CFTR modulator therapy for a minimum of 60 days prior to Screening and agree to maintain current regimen through the 24-month Observation Period
4. FEV1 ≥ 40% and \< 70% predicted (per Global Lung Function Initiative) at Screening, AND/OR experienced at least 2 pulmonary exacerbations in the last year requiring intravenous antibiotics
Key Exclusion Criteria (Primary and Sub Study):
1. Any prior gene therapy for any indication (Exception: mRNA-based or antisense oligonucleotide therapies are not exclusionary)
2. Active Mycobacterium abscessus infection requiring ongoing treatment at Screening
3. Active allergic bronchopulmonary aspergillosis requiring management with systemic corticosteroids or antifungal therapy
4. Smoking (e.g. cigarettes, cigars, cannabis) or use of a vaping product during the 2 months prior to screening; must agree to not smoke or use vaping products during Screening and initial 24-month observation period.
5. Contraindication to systemic corticosteroid therapy
6. Requires chronic use of systemic corticosteroids or immunosuppressants to treat another condition
7. If no known diagnosis of cystic fibrosis related diabetes (CFRD), Type I, or Type II diabetes: Hemoglobin A1C ≥ 6.5% at Screening
8. If known diagnosis of CFRD, Type I or Type II diabetes: Hemoglobin A1C \> 7.5% at Screening
9. Recent history of symptomatic hyperglycemia or unstable blood glucose levels as per Investigator's assessment
10. Other conditions that, in the Investigator's opinion, may interfere with management of corticosteroid-related hyperglycemia
11. Body Mass Index (BMI) \< 16
12. Laboratory abnormalities at screening:
* ALT, AST or GGT ≥ 3 × the upper limit of normal (ULN)
* Total bilirubin ≥ 2 × ULN
* Hemoglobin \< 10 g/dL
13. Requirement for continuous or night-time oxygen supplementation
14. Known CF liver disease with evidence of multilobular cirrhosis
15. History of thrombosis (excluding catheter-related thrombosis) or conditions associated with increased risk of thrombosis