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Dietary Supplementation With Blueberry in OA
Bu çalışma, osteoartrit (osteoarthritis) nedeniyle total diz protezi bekleyen hastalarda yaban mersini tozu takviyesinin etkilerini plaseboya benzer bir takviye (maltodekstrin) ile karşılaştırarak incelemektedir. Çalışmaya, diz osteoartriti olan ve total diz protezi planlanan, 40 yaş üstü hastalar alınmıştır. Faz uygulanmayan bir çalışma olup; şu an katılımcı almamakta ancak devam etmektedir (active, not recruiting).
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: * Participants capable of giving informed consent * Sex: Male and female * Age: \> 40 years - Those under 40 are more likely to have an undiagnosed secondary cause of osteoarthritis * BMI: \> 18 kg/m2 * Listed to have a total knee replacement for osteoarthritis * Participants are permitted to participate in other ongoing surgical intervention studies, as long as these are not trials of a dietary supplement or a medication. Exclusion Criteria: * Those who have received intravenous or oral immunosuppressant medications in past 2 years * Those who have had intra-articular steroid injection in 6 months preceding surgery. * Some secondary causes of osteoarthritis (mechanistic confounders that are likely to influence tissue inflammation measures: * Known congenital joint disorders * Other inflammatory arthritis e.g. rheumatoid arthritis * Avascular necrosis, infectious arthritis * Paget disease * Osteopetrosis * Osteochondritis dissecans * Hemochromatosis * Wilson's disease * Hemoglobinopathy * Ehlers-Danlos syndrome * Marfan syndrome * Acromegaly * Those typically consuming more than eight 80 g portions (or juice equivalent) of blueberries, blackberries, strawberries, raspberries, blackcurrants, pomegranate or cherries per week * Those with a known fruit allergy, for which they carry an adrenaline auto-injector or have required anti-histamine, adrenaline, glucocorticoid or beta-agonist treatment. * Those who cannot adequately understand verbal explanations or written information given in English