Yükleniyor... / Loading...
Personalized Metabolic Responses to Rapid, Slow and Resistant Starch
Bu çalışma, hızlı sindirilen, yavaş sindirilen ve dirençli nişasta türlerine karşı kişiden kişiye değişen metabolik yanıtları incelemektedir. Çalışmaya; 30-75 yaş arası, belirli vücut kitle indeksi ve bel çevresi ölçütlerini karşılayan erkekler ve menopoz sonrası kadınlar alınmaktadır. Chalmers University of Technology tarafından yürütülen faz uygulanmayan çalışma halen katılımcı almaktadır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria: * Men and post-menopausal women * Age 30-75 years * BMI 27-40 kg/m2 * Waist circumference \> 102/88 cm for men/women * Weight stable during previous 3 months (± 3 kg) * Willingness to consume the intervention diets * Ability to deal with the monitoring devices * Medications stable for the previous 14 days * Signed informed consent Exclusion Criteria: * Cardiovascular events (myocardial infarction or stroke) during the previous 6 months * Diagnosis of diabetes (any type) or use of any drug who can interfere with glucose homeostasis (i.e., metformin, incretin analogues, SGLT-2 inhibitors) * History of stomach or gastrointestinal conditions (inflammatory bowel disease, Crohn's disease, malabsorption, etc.) * Colostomy, bowel resection, bariatric surgery or other major gastrointestinal surgery * Renal or liver failure (creatinine \<1.7 mg/dl and alanine aminotransferase/aspartate aminotransferase \< 2 times than normal values, respectively) * Anemia (hemoglobin below the age and sex specific normal reference ranges at screening) * Blood donation (or participation in a clinical study with blood sampling) within 30 days prior to inclusion * Having been treated with antibiotics within the past 3 months or planning to undergo treatment during the study period. * Habitual use of probiotic/prebiotic supplements or foods enriched in probiotics * Celiac disease * Vegan/vegetarian diet (or a diet incompatible with protocol diets) * Intense physical activity regimen (\> 7 h/week of moderate intensity or \> 3 h/week of high intensity) * History of drug or alcohol abuse * Not able to understand written and spoken Swedish * Any other reason for lack of suitability for participation in the trial, as judged by the principal investor or co-principal investigator