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Physical Exercise and Biomolecular Analysis to Reduce Uremic Toxins in Chronic Kidney Disease: An Exploratory Study
Bu keşif amaçlı çalışma, kronik böbrek hastalığı (chronic kidney disease) olan bireylerde üremik toksinleri azaltmak amacıyla fiziksel egzersizin (direnç, dayanıklılık ve birleşik antrenman) etkisini biyomoleküler analizlerle incelemektedir. Çalışmaya; kalıcı albüminürisi ve metabolik sendromu bulunan, son altı aydır egzersiz programına katılmamış hastalar alınmaktadır. Catholic University of Brasília tarafından yürütülen faz uygulanmayan çalışma davetle katılım almaktadır.
Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.
Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.
Inclusion Criteria:
* those diagnosed with chronic kidney disease and presenting persistent albuminuria (\>300mg/g) following KDIGO guidelines;
* metabolic syndrome {i.e., type 2 diabetes mellitus, arterial hypertension (blood pressure \>180/100mmHg), overweight or obesity, and dyslipidemia};
* no complications arising from pre-existing clinical metabolic diseases (i.e., diabetic coma, ketoacidosis, hyperosmolarity, and/or uncontrolled diabetes), as evaluated by a nephrologist;
* absence of neurodegenerative, musculoskeletal, lupus erythematosus, or congenital kidney disease;
* no apparent cardiovascular complications, such as heart failure, severe arrhythmia, angina, or cerebrovascular disease;
* no comorbidities that limit performance in physical tests or training;
* not engaged in exercise programs for at least six months prior to the start of the experimental protocol;
* no smoking or alcohol consumption behavior;
* D-dimer values within normal range (220-500 ng/mL FEU)
Exclusion Criteria:
* regularly engage in physical exercise,
* have suffered a stroke in the last 6 months and/or present autoimmune diseases,
* have unstable cardiac dysfunctions, such as: uncontrolled coronary artery disease, aneurysm at risk of rupture, uncontrolled arrhythmia, uncontrolled hypertension (SBP \> 190 mmHg and/or DBP \> 100 mmHg), heart attack in the last 3 months;
* infectious conditions, Hb \< 8 in the last routine monthly hemodialysis exam;
* musculoskeletal pain;
* fever;
* resting SpO2 lower than 94%;
* restriction by the clinical team.