Hashimoto Tiroiditi Olan Çocuk ve Ergenlerde FGF-21 Düzeyleri ve İstirahat Metabolizma Hızı (THYROMETABOL)

Sade dilde özet

Bu çalışma, Hashimoto tiroiditi (Hashimoto's thyroiditis) olan çocuk ve ergenlerde FGF-21 düzeyleri ile istirahat metabolizma hızı (resting metabolic rate) arasındaki ilişkiyi incelemiştir. Çalışmaya, yeni tanı almış kronik otoimmün tiroidit hastaları ile sağlıklı kontrol olarak 5-18 yaş arası kişiler alınmıştır. Çalışma faz uygulanmayan bir araştırma olarak yürütülmüş ve tamamlanmıştır.

Yukarıdaki özet, resmî kaydın sade dile aktarılmış halidir. Orijinal İngilizce başlık referans için gösterilir.

Deney bilgileri

Faz

N/A

Durum

Tamamlandı

Sponsor

Aristotle University Of Thessaloniki

Başlangıç

01.10.2015

Tahmini bitiş

01.03.2020

Ülkeler

Greece

İlgili genler

Merkezler

• Thessaloniki, Greece

Uygunluk kriterleri

Kriterler ClinicalTrials.gov kaydından orijinal İngilizce haliyle alınmıştır. Uygunluk kararını yalnızca deneyi yürüten ekip verebilir.

Inclusion Criteria:

For patients

* Subjects 5 to 18 years old.
* First diagnosis of chronic autoimmune thyroiditis (high levels of serum antithyroid autoantibodies anti-TPO, anti-TgAb).

For Controls:

* Healthy individuals 5 to 18 years old.
* BMI for age between 15th and 85th percentile (z-score between -1 and +1).

Exclusion Criteria:

For patients

* Pre-existing medical treatment for thyroid disease
* Taking other medications (eg growth hormone, corticosteroids) in the last 3 months.
* Taking food supplements (eg omega-3 fatty acids, amino acids) in the last 3 months.
* Concomitant endocrine, metabolic, degenerative, and/or chronic diseases other than obesity (eg diabetes, hyper/ hypercortisolemia, cardiovascular diseases, kidney diseases, myasthenia, neurological diseases, psychiatric disorders eg anorexia nervosa, cancer, anemia, celiac disease, chromosomal abnormalities eg syndrome Turner, Down, etc).
* Participation in any daily organized physical activity (sport), more than 1 hour per day.
* Presence of menstrual disorders in adolescent girls.
* Having any kind of nutrition/dietary intervention (eg weight loss diet, hypocaloric, ketogenic, low-protein diet), in the last 6 months.

For Controls:

* Presence of any form of thyroid disease.
* Presence of any endocrine, metabolic, degenerative, and/or chronic disease (eg diabetes, hyper/ hypercortisolemia, obesity, metabolic syndrome, cardiovascular diseases, kidney diseases, myasthenia, neurological diseases, psychiatric disorders eg anorexia nervosa, cancer, anemia, celiac disease, chromosomal abnormalities eg syndrome Turner, Down, etc).
* Taking any medication (eg growth hormone, corticosteroids) in the last 3 months.
* Taking food supplements (eg omega-3 fatty acids, amino acids) in the last 3 months.
* Participation in any daily organized physical activity (sport), more than 1 hour per day. Presence of menstrual disorders in adolescent girls.
* Having any kind of nutrition/dietary intervention (eg weight loss diet, hypocaloric, ketogenic, low-protein diet), in the last 6 months.