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This study evaluates whether low-dose aspirin (acetylsalicylic acid) can prevent new or recurrent colorectal adenomas (bowel polyps) in patients with Lynch syndrome. It enrolls people, generally aged 25-75, who carry an alteration in mismatch repair genes or have a history of Lynch syndrome. It is being conducted in Phase 3; it is not currently recruiting but is still ongoing (active, not recruiting).
The summary above is a plain-language rendering of the official record. The original English title is shown for reference.
Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.
Inclusion Criteria: * Patient with Lynch syndrome bearing an alteration of "mismatch repair" genes or,when no characteristic alteration has been found, with a personal or family history of Lynch syndrome according to modified Amsterdam criteria * Aged more than 25 years, et aged more than 18 years with an early familial history and any reason to perform a colonoscopy every 2 years * Aged less than 75 years Exclusion Criteria: * Known allergy to aspirin (including a history of asthma induced by the administration of salicylates or substances with similar activity, including non-steroidal anti-inflammatory) * Need for a prolonged treatment (prevention of cardio-vascular risk) or repeated treatments (recurring migraines) using aspirin or another non-steroidal anti-inflammatory drug (NSAID) * Pregnancy or breast feeding * Participation to another clinical trial during the 12 weeks before inclusion