Small Bowel Capsule Endoscopy in Lynch Syndrome

Plain-language summary

This study looks at using small bowel capsule endoscopy to screen for (pre)neoplastic lesions in the small intestine of people with Lynch syndrome. People who carry a pathogenic variant in a DNA mismatch repair (MMR) gene (MLH1, MSH2, MSH6, PMS2, EPCAM) may take part. This is a study with no assigned phase and it is currently recruiting participants.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

N/A

Status

Recruiting

Sponsor

Assistance Publique - Hôpitaux de Paris

Start date

6/16/2025

Estimated completion

12/1/2026

Countries

France

Related genes

Locations

• Paris, France

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion Criteria:

* Patient carrying a pathogenic variant of the DNA mismatch repair gene (MMR) (MLH1, MSH2, MSH6, PMS2, EPCAM)
* Capsule endoscopy screening for (pre)neoplastic lesions of the small intestine
* No opposition to the reuse of healthcare data for research purposes

Exclusion Criteria:

* Absence of documented MMR gene variant
* Opposition to the study