Metabolic Flexibility in Patients With Early Triple-negative Breast Cancer

Plain-language summary

This study examines the effect of different exercise programs (cardiovascular training at maximal fat oxidation and at maximal aerobic power, plus resistance training) on metabolic flexibility in patients with early-stage triple-negative breast cancer. Women aged 20-55 with a newly diagnosed stage I-III triple-negative breast cancer who are candidates for neoadjuvant systemic treatment can take part. It is a study with no assigned phase and is active but not currently recruiting.

The summary above is a plain-language rendering of the official record. The original English title is shown for reference.

Trial details

Phase

Not Applicable

Status

Active, not recruiting

Sponsor

Universidad Europea de Madrid

Intervention

Cardiovascular training at maximal fat oxidation (FATmax), Cardiovascular training at maximal aerobic power (MAP), Resistance training

Start date

2/10/2026

Estimated completion

3/25/2028

Countries

Spain

Related genes

Locations

• Madrid, Spain

Eligibility criteria

Criteria are reproduced from the ClinicalTrials.gov record in the original English. Only the trial team can determine eligibility.

Inclusion criteria:

* Female between 20-55 years of age.
* Confirmed histological new diagnosis of stage I to III triple-negative breast cancer and a candidate to receive systemic neoadjuvant treatment with chemotherapy +/- immunotherapy.
* Must not have started systemic treatment for the neoplastic disease.
* Participating in any external physical exercise program or sports activities during the experimental study phase.
* Inability to understand and provide written Informed Consent (IC)

Exclusion Criteria:

* Having neurological or orthopedic disease at the time of recruitment or during the study evaluation and intervention.
* Inability to understand Spanish language.
* Presenting absolute contraindications for performing a cardiopulmonary exercise test (CPET) such as heart failure, myocarditis, acute pericarditis, severe aortic stenosis, aortic dissection, vascular toxicity, uncontrolled severe arterial hypertension, uncontrolled severe cardiac arrhythmias, pulmonary thromboembolism, or severe anemia.
* Have relative contraindications for performing a CPET such as bradyarrhythmias or tachyarrhythmias, moderate valvular stenosis, inability to perform physical or mental exertion, chronic infectious diseases, musculoskeletal disabilities, ventricular aneurysm, second- or third-degree atrioventricular block, or severe arterial hypertension.